I had some trouble running on Fedora 25 x86_64, rather than install all the libraries for the installer I extracted the files from ~/Myth2_181_Linux/files/required.zip.7z and copied them into the Myth2 folder. I'm not fussed about movies so I haven't tried to get those working.
I also had to install a few 32-bit libraries;
possibly also this if pulse doesn't install this
Because I'm using the old Nvidia drivers from rpmfusion repo, I also had to install the 32 bit driver support libraries to get accelerated 3D.
This will make all sound, HW 3D work on x11 with pulseaudio.
It might be nice to get a 64bit build so it will work out of the zip if anyone has a chance.